Authors: Daisuke Ueno, Teruyuki Matsuoka, Yuka Kato, Nobutaka Ayani, Saaya Maeda, Minato Takeda, Jin NarumotoTitle: Individual differences in interoceptive accuracy are correlated with salience network connectivity in older adults

Journal(書誌情報）: Frontiers in Aging Neuroscience

doi:10.3389/fnagi.2020.592002 

論文URL: https://www.frontiersin.org/articles/10.3389/fnagi.2020.592002/full

Abstract: Interoceptive accuracy refers to the ability to consciously perceive the physical condition of the inner body, including one’s heartbeat. In younger adults, interoceptive accuracy is correlated with insular and orbitofrontal cortical connectivity within the salience network (SN). As interoceptive accuracy and insular cortex volume are known to decrease with aging, we aimed to evaluate the correlation between SN connectivity and interoceptive accuracy in older adults. 27 older adults (mean age, 77.29 years, SD = 6.24; 19 female) underwent resting-state functional magnetic resonance imaging, followed by a heartbeat counting task and neuropsychological test. We evaluated the correlation between interoceptive accuracy and SN connectivity with age, sex, cognitive function, and total gray matter volume as covariates. Region of interest-to-region of interest analyses showed that interoceptive accuracy was positively correlated with the functional connectivity (FC) of the left rostral prefrontal cortex with the right insular, right orbitofrontal, and anterior cingulate cortices [F(6,16) = 4.52, false discovery rate (FDR)-corrected p < 0.05]. Moreover, interoceptive accuracy was negatively correlated to the FC of the left anterior insular cortex with right intra-calcarine and visual medial cortices (F(6,16) = 2.04, FDR-corrected p < 0.10). These findings suggest that coordination between systems, with a positive correlation between left rostral prefrontal cortex and the SN and a negative correlation between left insular cortex and vision-related exteroceptive brain regions, is important for maintaining interoceptive accuracy in older adults.

著者Contact先の email: dueno[at]koto.kpu-m.ac.jp（[at]を@に変更してください。）

日本語によるコメント：内受容感覚は，心拍や内臓などの身体内部に対する感覚の総称である。内受容感覚は感情や意思決定及び精神症状とも深い関わりがあり，加齢とともに正確に感じることが難しくなることが報告されている。本研究では，高齢者を対象に内受容感覚の正確性と関連する安静時の脳機能的結合を明らかにすることを目的とした。その結果，高齢者の内受容感覚の正確性は，若者と同様に顕著性ネットワークを基盤としつつも，多くの脳領域と正の相関がみられ，外受容感覚と関連する視覚野領域と負の相関がみられた。これらの結果は，高齢者が内受容感覚を維持するために，若者よりも多くの脳領域の調整が必要であることを示唆する。

投稿タグ