Authors: Kenta Matsumura, Kei Hamazaki, Akiko Tsuchida, Haruka Kasamatsu, Hidekuni Inadera, and the JECS Group

Title: Causal model of the association of social support during pregnancy with a perinatal and postpartum depressive state: A nationwide birth cohort–the Japan Environment and Children’s Study

Journal(書誌情報）: Journal of Affective Disorders

doi: 10.1016/j.jad.2021.12.117

論文URL: https://doi.org/10.1016/j.jad.2021.12.117

Background: Despite many epidemiological studies on the relationship between social support during pregnancy and perinatal/postpartum depression, its impact remains unclear. Therefore, this study examined this association using a causal model of risk based on various levels of social support.
Methods: Participants were 88,711 mothers in an ongoing nationwide birth cohort study in Japan. Social support during pregnancy was set at four treatment levels. Depressive state was identified twice, with the Kessler Psychological Distress Scale (K6; score ≥ 5) and the Edinburgh Postnatal Depression Scale (EPDS; score ≥ 9). With the highest level of social support set as reference, marginal structural models were fitted to derive counterfactual risk ratios (cRRs).
Results: cRRs (95% CIs) for EPDS cases increased as the level of social support decreased, with values of 1.06 (0.99–1.13) for upper-middle, 1.30 (1.23–1.39) for lower-middle, and 1.61 (1.52–1.71) for low. Also, cRRs (95% CIs) at the second measurement (interaction) tended to increase as social support decreased, with values of 1.05 (0.97–1.13) for upper-middle, 1.05 (0.98–1.13) for lower-middle, and 1.10 (1.03–1.18) for low. The same tendency was observed in K6 cases.
Limitation: Depressive state was identified by self-administered questionnaire.
Conclusions: Lower social support during pregnancy is associated with increased counterfactual risk of perinatal/postpartum depressive state and worsened counterfactual spontaneous recovery over time. These findings highlight the importance of sufficient social support for preventing perinatal/postpartum depression and promoting recovery.

著者Contact先の email: kmatsumu[at]med.u-toyama.ac.jp（[at]を@に変更してください。）

日本語によるコメント：反事実仮定に基づく統計的因果推論を用いた出生コホート論文です。逆確率重み付けで疑似集団を作り周辺構造モデルを使って解析しました。解析の結果、妊娠中のソーシャル・サポートは妊娠中から産後1年にかけての抑うつ状態の予防に効果的であるだけでなく、抑うつ状態からの自発的回復も促進すると分かりました。

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